General information
PDB ID 5UAN
Title CRYSTAL STRUCTURE OF MULTI-DOMAIN RAR-BETA-RXR-ALPHA HETERODIMER ON DNA
PDB header TRANSCRIPTION/DNA
Date 2016-12-19
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.51
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5uan.pdb ABCD EF 0
Biounits:
5uan.pdb1.pdb ABCD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Hormone_recep Domain P19793_263-442 1.7e-37 1 No_clan A 242 442   
zf-C4 Domain P19793_133-202 3.8e-20 1 CL0167 A 133 202 EF  H-Bb H-Mj S-Bb L-Bb 
zf-C4 Domain P10826_87-155 1.5e-32 1 CL0167 B 80 148 EF  H-Bb H-Mj S-Bb L-Bb 
Hormone_recep Domain P10826_224-401 2.7e-23 1 No_clan B 217 394   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=98-462 C mitochondrion
A=98-462 C nuclear chromatin
A=98-462 C nucleoplasm
A=98-462 C nucleus
A=98-462 C protein-containing complex
A=98-462 C receptor complex
A=98-462 C RNA polymerase II transcription regulator complex
A=98-462 F chromatin DNA binding
A=98-462 F DNA binding domain binding
A=98-462 F DNA-binding transcription factor activity
A=98-462 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=98-462 F double-stranded DNA binding
A=98-462 F enzyme binding
A=98-462 F identical protein binding
A=98-462 F LBD domain binding
A=98-462 F nuclear receptor activity
A=98-462 F nuclear receptor binding
A=98-462 F peptide binding
A=98-462 F retinoic acid binding
A=98-462 F retinoic acid-responsive element binding
A=98-462 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=98-462 F RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
A=98-462 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A=98-462 F sequence-specific DNA binding
A=98-462 F sequence-specific double-stranded DNA binding
A=98-462 F steroid hormone receptor activity
A=98-462 F transcription regulatory region sequence-specific DNA binding
A=98-462 F vitamin D receptor binding
A=98-462 F zinc ion binding
A=98-462 P anatomical structure development
A=98-462 P bile acid and bile salt transport
A=98-462 P camera-type eye development
A=98-462 P cardiac muscle cell proliferation
A=98-462 P cell differentiation
A=98-462 P cholesterol metabolic process
A=98-462 P embryo implantation
A=98-462 P in utero embryonic development
A=98-462 P maternal placenta development
A=98-462 P modulation by virus of host process
A=98-462 P negative regulation of transcription by RNA polymerase II
A=98-462 P peroxisome proliferator activated receptor signaling pathway
A=98-462 P positive regulation of transcription by RNA polymerase II
A=98-462 P positive regulation of transcription, DNA-templated
A=98-462 P positive regulation of translational initiation by iron
A=98-462 P regulation of branching involved in prostate gland morphogenesis
A=98-462 P regulation of lipid metabolic process
A=98-462 P regulation of transcription by RNA polymerase II
A=98-462 P response to retinoic acid
A=98-462 P retinoic acid receptor signaling pathway
A=98-462 P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
A=98-462 P transcription initiation from RNA polymerase II promoter
A=98-462 P ventricular cardiac muscle cell differentiation
A=98-462 P ventricular cardiac muscle tissue morphogenesis
B=80-455 C cytoplasm
B=80-455 C nuclear chromatin
B=80-455 C nucleoplasm
B=80-455 C nucleus
B=80-455 C RNA polymerase II transcription regulator complex
B=80-455 F DNA binding
B=80-455 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=80-455 F drug binding
B=80-455 F nuclear receptor activity
B=80-455 F protein-containing complex binding
B=80-455 F retinoid X receptor binding
B=80-455 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
B=80-455 F sequence-specific double-stranded DNA binding
B=80-455 F signaling receptor activity
B=80-455 F transcription factor binding
B=80-455 F zinc ion binding
B=80-455 P cell differentiation
B=80-455 P embryonic digestive tract development
B=80-455 P embryonic eye morphogenesis
B=80-455 P embryonic hindlimb morphogenesis
B=80-455 P glandular epithelial cell development
B=80-455 P growth plate cartilage development
B=80-455 P hormone-mediated signaling pathway
B=80-455 P multicellular organism growth
B=80-455 P negative regulation of apoptotic process
B=80-455 P negative regulation of cell population proliferation
B=80-455 P negative regulation of chondrocyte differentiation
B=80-455 P negative regulation of transcription by RNA polymerase II
B=80-455 P outflow tract septum morphogenesis
B=80-455 P positive regulation of apoptotic process
B=80-455 P positive regulation of neuron differentiation
B=80-455 P positive regulation of transcription by RNA polymerase II
B=80-455 P regulation of myelination
B=80-455 P retinoic acid receptor signaling pathway
B=80-455 P signal transduction
B=80-455 P striatum development
B=80-455 P transcription initiation from RNA polymerase II promoter
B=80-455 P ureteric bud development
B=80-455 P ventricular cardiac muscle cell differentiation
C/D=687-696 C cytoplasm
C/D=687-696 C nuclear body
C/D=687-696 C nuclear chromatin
C/D=687-696 C nucleoplasm
C/D=687-696 C nucleus
C/D=687-696 C protein-containing complex
C/D=687-696 F aryl hydrocarbon receptor binding
C/D=687-696 F chromatin binding
C/D=687-696 F DNA-binding transcription factor activity, RNA polymerase II-specific
C/D=687-696 F nuclear hormone receptor binding
C/D=687-696 F nuclear receptor binding
C/D=687-696 F nuclear receptor transcription coactivator activity
C/D=687-696 F protein dimerization activity
C/D=687-696 F protein domain specific binding
C/D=687-696 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C/D=687-696 F RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
C/D=687-696 F thyroid hormone receptor coactivator activity
C/D=687-696 F transcription coactivator activity
C/D=687-696 P bile acid and bile salt transport
C/D=687-696 P cellular response to hormone stimulus
C/D=687-696 P cellular response to Thyroglobulin triiodothyronine
C/D=687-696 P circadian regulation of gene expression
C/D=687-696 P locomotor rhythm
C/D=687-696 P negative regulation of transcription by RNA polymerase II
C/D=687-696 P positive regulation of transcription by RNA polymerase II
C/D=687-696 P regulation of glucose metabolic process
C/D=687-696 P regulation of lipid metabolic process
C/D=687-696 P regulation of transcription, DNA-templated
C/D=687-696 P response to progesterone
Sequences
Download file with secondary structure created by Stride  
5uan.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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