General information
PDB ID 5ZEN
Title CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH DNA: A NEW QUATERNARY CONFORMATION SHOWING OPENING OF THE PROTEIN-LINKED DNA-GATE
PDB header ISOMERASE/DNA
Date 2018-02-27
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.75
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5zen.pdb A BC 0
Biounits:
5zen.pdb1.pdb A BC 2
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_topoisoIV Family Q02880_734-1190 1.5e-134 1 No_clan A 729 1185 BC  H-Bb H-Mj S-Bb S-Mj S-Mn L-Bb 
TOPRIM_C Family Q02880_594-732 8.7e-37 1 No_clan A 589 727 C  H-Bb 
Toprim Family Q02880_477-592 1e-09 1 CL0413 A 472 587 BC  H-Bb S-Bb L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=450-1206 C cytosol
A=450-1206 C nucleoplasm
A=450-1206 C nucleus
A=450-1206 C ribonucleoprotein complex
A=450-1206 C viral integration complex
A=450-1206 F ATP binding
A=450-1206 F chromatin binding
A=450-1206 F DNA binding
A=450-1206 F DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A=450-1206 F enzyme binding
A=450-1206 F histone deacetylase binding
A=450-1206 F metal ion binding
A=450-1206 F protein C-terminus binding
A=450-1206 F protein heterodimerization activity
A=450-1206 F protein kinase C binding
A=450-1206 P axonogenesis
A=450-1206 P DNA topological change
A=450-1206 P forebrain development
A=450-1206 P mitotic DNA integrity checkpoint
A=450-1206 P neuron migration
A=450-1206 P positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
A=450-1206 P resolution of meiotic recombination intermediates
A=450-1206 P sister chromatid segregation
Sequences
Download file with secondary structure created by Stride  
5zen.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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