General information
PDB ID 6KIV
Title CRYO-EM STRUCTURE OF HUMAN MLL1-UBNCP COMPLEX (4.0 ANGSTROM)
PDB header TRANSCRIPTION/DNA
Date 2019-07-20
Experimental method ELECTRON MICROSCOPY
Resolution (A) 4
Kind dna
Organism XENOPUS LAEVIS, SYNTHETIC CONSTRUCT, HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6kiv.pdb ABCDEFGHKNOTR IJ 0
Biounits:
6kiv.pdb1.pdb ABCDEFGHKNOTR IJ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Histone Domain P84233_37-132 7.9e-46 1 CL0012 A 38 131 IJ  H-Bb S-Bb L-Bb L-Mn 
CENP-T_C Domain P62799_18-99 5e-08 1 CL0012 B 20 98 IJ  H-Bb L-Bb 
Histone Domain P06897_13-91 5.6e-16 1 CL0012 C 11 90 IJ  H-Bb S-Bb L-Bb 
Histone Domain P02281_33-102 4e-22 1 CL0012 D 27 98 IJ  H-Bb L-Bb 
Histone Domain P84233_37-132 7.9e-46 1 CL0012 E 38 131 IJ  H-Bb L-Bb L-Mn 
CENP-T_C Domain P62799_26-99 4.6e-08 1 CL0012 F 25 98 IJ  H-Bb L-Bb 
Histone Domain P06897_13-91 6.6e-16 1 CL0012 G 13 90 IJ  S-Bb L-Bb 
Histone Domain P02281_33-102 7.2e-22 1 CL0012 H 28 98 IJ  H-Bb L-Bb 
ubiquitin Domain P62979_3-74 5.5e-35 1 CL0072 O 3 74   
Histone_H2A_C Family P06897_92-126 2.3e-19 1 No_clan C 91 122 I  L-Mj 
Histone_H2A_C Family P06897_92-120 2.9e-16 1 No_clan G 91 117   
SET Family Q03164_3840-3945 3.7e-23 1 No_clan K 3840 3945 J  S-Bb 
SPRY Family Q9UBL3_420-494 4.4e-17 1 CL0004 T 326 486   
WD40 Repeat Q15291_58-94 0.00024 1 CL0186 N 58 94   
WD40 Repeat P61964_77-115 4.5e-10 1 CL0186 R 119 157   
WD40 Repeat P61964_77-115 4.3e-09 1 CL0186 R 161 199   
WD40 Repeat P61964_35-72 7.2e-09 1 CL0186 R 36 72   
WD40 Repeat P61964_77-115 7.3e-09 1 CL0186 R 77 115   
WD40 Repeat P61964_246-287 2e-05 1 CL0186 R 246 287   
WD40 Repeat P61964_203-242 2e-05 1 CL0186 R 203 242   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/E=2-136 C nucleoplasm
A/E=2-136 C nucleosome
A/E=2-136 F DNA binding
A/E=2-136 F protein heterodimerization activity
B/F=2-103 C host cell nucleus
B/F=2-103 C nucleosome
B/F=2-103 C nucleus
B/F=2-103 F DNA binding
B/F=2-103 F protein heterodimerization activity
B/F=2-103 P DNA-templated transcription, initiation
C/G=2-130 C nucleosome
C/G=2-130 C nucleus
C/G=2-130 F DNA binding
C/G=2-130 F protein heterodimerization activity
D/H=5-126 C nucleosome
D/H=5-126 C nucleus
D/H=5-126 F DNA binding
D/H=5-126 F protein heterodimerization activity
K=3754-3969 C cytosol
K=3754-3969 C histone methyltransferase complex
K=3754-3969 C MLL1 complex
K=3754-3969 C nucleoplasm
K=3754-3969 C nucleus
K=3754-3969 F AT DNA binding
K=3754-3969 F DNA-binding transcription factor activity, RNA polymerase II-specific
K=3754-3969 F histone methyltransferase activity (H3-K4 specific)
K=3754-3969 F identical protein binding
K=3754-3969 F lysine-acetylated histone binding
K=3754-3969 F protein homodimerization activity
K=3754-3969 F transcription regulatory region sequence-specific DNA binding
K=3754-3969 F unmethylated CpG binding
K=3754-3969 F zinc ion binding
K=3754-3969 P apoptotic process
K=3754-3969 P circadian regulation of gene expression
K=3754-3969 P embryonic hemopoiesis
K=3754-3969 P histone H3-K4 dimethylation
K=3754-3969 P histone H3-K4 methylation
K=3754-3969 P histone H3-K4 monomethylation
K=3754-3969 P histone H3-K4 trimethylation
K=3754-3969 P histone H4-K16 acetylation
K=3754-3969 P negative regulation of DNA methylation
K=3754-3969 P positive regulation of cellular response to drug
K=3754-3969 P positive regulation of histone H3-K4 methylation
K=3754-3969 P positive regulation of transcription by RNA polymerase II
K=3754-3969 P positive regulation of transcription, DNA-templated
K=3754-3969 P positive regulation of transporter activity
K=3754-3969 P protein-containing complex assembly
K=3754-3969 P regulation of hematopoietic stem cell differentiation
K=3754-3969 P regulation of histone H3-K14 acetylation
K=3754-3969 P regulation of histone H3-K9 acetylation
K=3754-3969 P regulation of megakaryocyte differentiation
N=1-538 C histone methyltransferase complex
N=1-538 C MLL1 complex
N=1-538 C MLL3/4 complex
N=1-538 C nucleolus
N=1-538 C nucleoplasm
N=1-538 C nucleus
N=1-538 C Set1C/COMPASS complex
N=1-538 F methylated histone binding
N=1-538 F transcription regulatory region sequence-specific DNA binding
N=1-538 P beta-catenin-TCF complex assembly
N=1-538 P cellular response to DNA damage stimulus
N=1-538 P histone H3-K4 methylation
N=1-538 P post-translational protein modification
N=1-538 P regulation of megakaryocyte differentiation
N=1-538 P response to estrogen
O=1-76 C cytoplasm
O=1-76 C cytosol
O=1-76 C cytosolic small ribosomal subunit
O=1-76 C endocytic vesicle membrane
O=1-76 C endoplasmic reticulum membrane
O=1-76 C endosome membrane
O=1-76 C extracellular exosome
O=1-76 C extracellular space
O=1-76 C host cell
O=1-76 C membrane
O=1-76 C mitochondrial outer membrane
O=1-76 C nucleolus
O=1-76 C nucleoplasm
O=1-76 C nucleus
O=1-76 C plasma membrane
O=1-76 C small ribosomal subunit
O=1-76 C vesicle
O=1-76 F metal ion binding
O=1-76 F protein tag
O=1-76 F RNA binding
O=1-76 F structural constituent of ribosome
O=1-76 F ubiquitin protein ligase binding
O=1-76 P activation of MAPK activity
O=1-76 P anaphase-promoting complex-dependent catabolic process
O=1-76 P cellular protein metabolic process
O=1-76 P cytokine-mediated signaling pathway
O=1-76 P DNA damage response, detection of DNA damage
O=1-76 P endosomal transport
O=1-76 P error-free translesion synthesis
O=1-76 P error-prone translesion synthesis
O=1-76 P global genome nucleotide-excision repair
O=1-76 P I-kappaB kinase/NF-kappaB signaling
O=1-76 P interleukin-1-mediated signaling pathway
O=1-76 P interstrand cross-link repair
O=1-76 P intracellular transport of virus
O=1-76 P JNK cascade
O=1-76 P membrane organization
O=1-76 P modification-dependent protein catabolic process
O=1-76 P MyD88-dependent toll-like receptor signaling pathway
O=1-76 P MyD88-independent toll-like receptor signaling pathway
O=1-76 P negative regulation of apoptotic process
O=1-76 P negative regulation of transcription by RNA polymerase II
O=1-76 P negative regulation of transforming growth factor beta receptor signaling pathway
O=1-76 P nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
O=1-76 P nucleotide-binding oligomerization domain containing signaling pathway
O=1-76 P nucleotide-excision repair, DNA damage recognition
O=1-76 P nucleotide-excision repair, DNA duplex unwinding
O=1-76 P nucleotide-excision repair, DNA gap filling
O=1-76 P nucleotide-excision repair, DNA incision
O=1-76 P nucleotide-excision repair, DNA incision, 5'-to lesion
O=1-76 P nucleotide-excision repair, preincision complex assembly
O=1-76 P positive regulation of apoptotic process
O=1-76 P positive regulation of NF-kappaB transcription factor activity
O=1-76 P positive regulation of transcription by RNA polymerase II
O=1-76 P protein deubiquitination
O=1-76 P protein polyubiquitination
O=1-76 P protein targeting to peroxisome
O=1-76 P protein ubiquitination
O=1-76 P regulation of mRNA stability
O=1-76 P regulation of transcription from RNA polymerase II promoter in response to hypoxia
O=1-76 P SRP-dependent cotranslational protein targeting to membrane
O=1-76 P stress-activated MAPK cascade
O=1-76 P transcription-coupled nucleotide-excision repair
O=1-76 P transforming growth factor beta receptor signaling pathway
O=1-76 P translation
O=1-76 P translational initiation
O=1-76 P translesion synthesis
O=1-76 P transmembrane transport
O=1-76 P TRIF-dependent toll-like receptor signaling pathway
O=1-76 P viral life cycle
O=1-76 P viral transcription
O=1-76 P virion assembly
O=1-76 P Wnt signaling pathway
R=1-334 C Ada2/Gcn5/Ada3 transcription activator complex
R=1-334 C histone acetyltransferase complex
R=1-334 C histone methyltransferase complex
R=1-334 C MLL1 complex
R=1-334 C MLL3/4 complex
R=1-334 C nucleoplasm
R=1-334 C nucleus
R=1-334 C Set1C/COMPASS complex
R=1-334 F histone binding
R=1-334 F methylated histone binding
R=1-334 P histone H3 acetylation
R=1-334 P histone H3-K4 methylation
R=1-334 P histone H4-K16 acetylation
R=1-334 P histone H4-K5 acetylation
R=1-334 P histone H4-K8 acetylation
R=1-334 P negative regulation of histone H3-K4 methylation
R=1-334 P neuron projection development
R=1-334 P positive regulation of gluconeogenesis
R=1-334 P positive regulation of histone H3-K4 methylation
R=1-334 P post-translational protein modification
R=1-334 P regulation of megakaryocyte differentiation
R=1-334 P skeletal system development
T=95-628 C histone methyltransferase complex
T=95-628 C MLL1 complex
T=95-628 C MLL3/4 complex
T=95-628 C nuclear euchromatin
T=95-628 C nucleoplasm
T=95-628 C nucleus
T=95-628 C Set1C/COMPASS complex
T=95-628 F beta-catenin binding
T=95-628 F euchromatin binding
T=95-628 F metal ion binding
T=95-628 F transcription regulatory region sequence-specific DNA binding
T=95-628 P beta-catenin-TCF complex assembly
T=95-628 P cellular response to DNA damage stimulus
T=95-628 P hemopoiesis
T=95-628 P histone H3-K4 methylation
T=95-628 P positive regulation of cell population proliferation
T=95-628 P positive regulation of transcription by RNA polymerase II
T=95-628 P regulation of megakaryocyte differentiation
T=95-628 P response to estrogen
Sequences
Download file with secondary structure created by Stride  
6kiv.pdb1.pdb:   [ download sequences in FASTA format ]
I (dna): 
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J (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (protein): 
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F (protein): 
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G (protein): 
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H (protein): 
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K (protein): 
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N (protein): 
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O (protein): 
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R (protein): 
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T (protein): 
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