General information
PDB ID 6MUP
Title CENP-A NUCLEOSOME BOUND BY TWO COPIES OF CENP-C(CD) AND TWO COPIES CENP-N(NT)
PDB header NUCLEAR PROTEIN
Date 2018-10-23
Experimental method ELECTRON MICROSCOPY
Resolution (A) 3.5
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6mup.pdb ABCDEFGHKLMN IJ 0
Biounits:
6mup.pdb1.pdb ABCDEFGHKLMN IJ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Histone Domain P49450_42-133 9.4e-35 1 CL0012 A 38 133 IJ   
CENP-T_C Domain P62805_19-99 6e-08 1 CL0012 B 21 98 IJ   
Histone Domain Q93077_16-91 5.4e-16 1 CL0012 C 14 90 IJ   
Histone Domain Q5QNW6_34-102 3.1e-21 1 CL0012 D 33 101 IJ   
Histone Domain P49450_42-133 1.2e-34 1 CL0012 E 39 133 IJ   
CENP-T_C Domain P62805_19-99 6e-08 1 CL0012 F 21 98 IJ   
Histone Domain Q93077_16-91 3.8e-16 1 CL0012 G 13 90 IJ   
Histone Domain Q5QNW6_34-102 3.1e-21 1 CL0012 H 33 101 IJ   
Histone_H2A_C Family Q93077_92-115 2.5e-15 1 No_clan C 91 116   
Histone_H2A_C Family Q93077_92-115 2.9e-16 1 No_clan G 91 117   
CENP-C_mid Family Q03188_520-537 1.4e-08 1 No_clan K 518 537   
CENP-C_mid Family Q03188_520-537 6.8e-08 1 No_clan L 519 537   
CENP-N Family Q96H22_3-212 4.5e-41 1 No_clan M 3 212 IJ   
CENP-N Family Q96H22_3-212 4.5e-41 1 No_clan N 3 212 IJ   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/E=38-139 C chromosome, centromeric region
A/E=38-139 C condensed chromosome inner kinetochore
A/E=38-139 C condensed nuclear chromosome kinetochore
A/E=38-139 C condensed nuclear chromosome, centromeric region
A/E=38-139 C cytosol
A/E=38-139 C nuclear nucleosome
A/E=38-139 C nuclear pericentric heterochromatin
A/E=38-139 C nucleoplasm
A/E=38-139 C nucleus
A/E=38-139 F chromatin binding
A/E=38-139 F DNA binding
A/E=38-139 F protein heterodimerization activity
A/E=38-139 P CENP-A containing nucleosome assembly
A/E=38-139 P establishment of mitotic spindle orientation
A/E=38-139 P kinetochore assembly
A/E=38-139 P mitotic cytokinesis
A/E=38-139 P protein localization to chromosome, centromeric region
A/E=38-139 P viral process
B/F=9-102 C extracellular exosome
B/F=9-102 C extracellular region
B/F=9-102 C host cell nucleus
B/F=9-102 C membrane
B/F=9-102 C nuclear chromosome
B/F=9-102 C nuclear chromosome, telomeric region
B/F=9-102 C nuclear nucleosome
B/F=9-102 C nucleoplasm
B/F=9-102 C nucleosome
B/F=9-102 C nucleus
B/F=9-102 C protein-containing complex
B/F=9-102 F DNA binding
B/F=9-102 F protein domain specific binding
B/F=9-102 F protein heterodimerization activity
B/F=9-102 F RNA binding
B/F=9-102 P cellular protein metabolic process
B/F=9-102 P CENP-A containing nucleosome assembly
B/F=9-102 P DNA replication-dependent nucleosome assembly
B/F=9-102 P DNA replication-independent nucleosome assembly
B/F=9-102 P DNA-templated transcription, initiation
B/F=9-102 P double-strand break repair via nonhomologous end joining
B/F=9-102 P negative regulation of gene expression, epigenetic
B/F=9-102 P negative regulation of megakaryocyte differentiation
B/F=9-102 P nucleosome assembly
B/F=9-102 P rDNA heterochromatin assembly
B/F=9-102 P regulation of gene silencing by miRNA
B/F=9-102 P regulation of megakaryocyte differentiation
B/F=9-102 P telomere capping
B/F=9-102 P telomere organization
C/G=14-118 C extracellular exosome
C/G=14-118 C nuclear chromatin
C/G=14-118 C nucleoplasm
C/G=14-118 C nucleosome
C/G=14-118 C nucleus
C/G=14-118 F DNA binding
C/G=14-118 F protein heterodimerization activity
C/G=14-118 P chromatin organization
C/G=14-118 P chromatin silencing
C/G=14-118 P negative regulation of cell population proliferation
D/H=34-125 C cytosol
D/H=34-125 C extracellular exosome
D/H=34-125 C nucleoplasm
D/H=34-125 C nucleosome
D/H=34-125 C nucleus
D/H=34-125 F DNA binding
D/H=34-125 F protein heterodimerization activity
D/H=34-125 P nucleosome assembly
K/L=518-537 C condensed nuclear chromosome kinetochore
K/L=518-537 C condensed nuclear chromosome, centromeric region
K/L=518-537 C cytosol
K/L=518-537 C kinetochore
K/L=518-537 C midbody
K/L=518-537 C nuclear body
K/L=518-537 C nucleoplasm
K/L=518-537 C pericentric heterochromatin
K/L=518-537 F centromeric DNA binding
K/L=518-537 F DNA binding
K/L=518-537 F identical protein binding
K/L=518-537 P attachment of mitotic spindle microtubules to kinetochore
K/L=518-537 P cell division
K/L=518-537 P CENP-A containing nucleosome assembly
K/L=518-537 P chromosome segregation
K/L=518-537 P kinetochore assembly
K/L=518-537 P mitotic cell cycle
K/L=518-537 P monopolar spindle attachment to meiosis I kinetochore
M/N=1-212 C condensed chromosome kinetochore
M/N=1-212 C cytosol
M/N=1-212 C nucleoplasm
M/N=1-212 P CENP-A containing nucleosome assembly
M/N=1-212 P chromosome segregation
M/N=1-212 P kinetochore assembly
Sequences
Download file with secondary structure created by Stride  
6mup.pdb1.pdb:   [ download sequences in FASTA format ]
I (dna): 
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J (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (protein): 
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F (protein): 
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G (protein): 
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H (protein): 
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K (protein): 
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L (protein): 
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M (protein): 
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N (protein): 
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