General information
PDB ID 6PA7
Title THE CRYO-EM STRUCTURE OF THE HUMAN DNMT3A2-DNMT3B3 COMPLEX BOUND TO NUCLEOSOME.
PDB header TRANSFERASE/DNA
Date 2019-06-11
Experimental method ELECTRON MICROSCOPY
Resolution (A) 2.94
Kind dna
Organism XENOPUS LAEVIS, SYNTHETIC CONSTRUCT, HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6pa7.pdb ABCDEFGHKNPS IJ 0
Biounits:
6pa7.pdb1.pdb ABCDEFGHKNPS IJ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Histone Domain P84233_39-132 4e-46 1 CL0012 A 37 131 IJ  H-Bb H-Mj S-Bb L-Bb L-Mn 
CENP-T_C Domain P62799_26-99 4.6e-08 1 CL0012 B 25 98 IJ  S-Bb L-Bb 
Histone Domain P06897_13-91 5e-16 1 CL0012 C 11 90 IJ  H-Bb S-Bb L-Bb 
Histone Domain P02281_33-102 6.9e-22 1 CL0012 D 28 98 IJ  H-Bb H-Mj S-Bb L-Bb 
Histone Domain P84233_39-132 3.8e-46 1 CL0012 E 37 131 IJ  H-Bb H-Mj S-Bb L-Bb L-Mn 
CENP-T_C Domain P62799_21-99 4.9e-08 1 CL0012 F 25 98 IJ  S-Bb L-Bb 
Histone Domain P06897_13-91 4.8e-16 1 CL0012 G 10 90 IJ  H-Bb S-Bb L-Bb 
Histone Domain P02281_33-102 4.3e-22 1 CL0012 H 27 98 IJ  H-Bb S-Bb L-Bb 
DNA_methylase Domain Q9Y6K1_634-776 1e-12 1 CL0063 K 634 782 I  L-Bb 
DNA_methylase Domain Q9Y6K1_634-776 1e-12 1 CL0063 P 634 782   
Histone_H2A_C Family P06897_92-119 3.2e-17 1 No_clan C 91 118   
Histone_H2A_C Family P06897_92-119 8.7e-19 1 No_clan G 91 120   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/E=2-136 C nucleoplasm
A/E=2-136 C nucleosome
A/E=2-136 F DNA binding
A/E=2-136 F protein heterodimerization activity
B/F=1-103 C host cell nucleus
B/F=1-103 C nucleosome
B/F=1-103 C nucleus
B/F=1-103 F DNA binding
B/F=1-103 F protein heterodimerization activity
B/F=1-103 P DNA-templated transcription, initiation
C/G=2-130 C nucleosome
C/G=2-130 C nucleus
C/G=2-130 F DNA binding
C/G=2-130 F protein heterodimerization activity
D/H=5-126 C nucleosome
D/H=5-126 C nucleus
D/H=5-126 F DNA binding
D/H=5-126 F protein heterodimerization activity
K/P=224-912 C chromosome, centromeric region
K/P=224-912 C cytoplasm
K/P=224-912 C euchromatin
K/P=224-912 C nuclear heterochromatin
K/P=224-912 C nuclear matrix
K/P=224-912 C nucleoplasm
K/P=224-912 C nucleus
K/P=224-912 C XY body
K/P=224-912 F chromatin binding
K/P=224-912 F DNA (cytosine-5-)-methyltransferase activity
K/P=224-912 F DNA binding
K/P=224-912 F DNA-methyltransferase activity
K/P=224-912 F identical protein binding
K/P=224-912 F metal ion binding
K/P=224-912 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
K/P=224-912 F transcription corepressor activity
K/P=224-912 F transcription factor binding
K/P=224-912 P aging
K/P=224-912 P cellular response to amino acid stimulus
K/P=224-912 P cellular response to ethanol
K/P=224-912 P cellular response to hypoxia
K/P=224-912 P DNA methylation
K/P=224-912 P DNA methylation involved in embryo development
K/P=224-912 P DNA methylation involved in gamete generation
K/P=224-912 P DNA methylation-dependent heterochromatin assembly
K/P=224-912 P hepatocyte apoptotic process
K/P=224-912 P mitotic cell cycle
K/P=224-912 P negative regulation of gene expression, epigenetic
K/P=224-912 P negative regulation of transcription by RNA polymerase II
K/P=224-912 P neuron differentiation
K/P=224-912 P positive regulation of cell death
K/P=224-912 P regulation of gene expression by genetic imprinting
K/P=224-912 P response to cocaine
K/P=224-912 P response to drug
K/P=224-912 P response to estradiol
K/P=224-912 P response to ionizing radiation
K/P=224-912 P response to lead ion
K/P=224-912 P response to toxic substance
K/P=224-912 P response to vitamin A
K/P=224-912 P spermatogenesis
N/S=1-853 C nucleoplasm
N/S=1-853 C nucleus
N/S=1-853 F chromatin binding
N/S=1-853 F DNA (cytosine-5-)-methyltransferase activity
N/S=1-853 F DNA binding
N/S=1-853 F DNA-methyltransferase activity
N/S=1-853 F histone deacetylase binding
N/S=1-853 F metal ion binding
N/S=1-853 F transcription corepressor activity
N/S=1-853 P cellular response to dexamethasone stimulus
N/S=1-853 P cellular response to hyperoxia
N/S=1-853 P DNA methylation
N/S=1-853 P negative regulation of gene expression, epigenetic
N/S=1-853 P negative regulation of histone H3-K9 methylation
N/S=1-853 P negative regulation of transcription by RNA polymerase II
N/S=1-853 P positive regulation of gene expression
N/S=1-853 P positive regulation of histone H3-K4 methylation
N/S=1-853 P positive regulation of neuron differentiation
N/S=1-853 P response to activity
N/S=1-853 P response to caffeine
N/S=1-853 P response to cocaine
N/S=1-853 P response to drug
N/S=1-853 P response to estradiol
N/S=1-853 P response to hypoxia
N/S=1-853 P response to ionizing radiation
N/S=1-853 P response to toxic substance
N/S=1-853 P response to vitamin A
Sequences
Download file with secondary structure created by Stride  
6pa7.pdb1.pdb:   [ download sequences in FASTA format ]
I (dna): 
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J (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (protein): 
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F (protein): 
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G (protein): 
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H (protein): 
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K (protein): 
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N (protein): 
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P (protein): 
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S (protein): 
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