General information
PDB ID 6S1N
Title HUMAN POLYMERASE DELTA HOLOENZYME CONFORMER 2
PDB header REPLICATION
Date 2019-06-19
Experimental method ELECTRON MICROSCOPY
Resolution (A) 4.86
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6s1n.pdb ABCDEFG PT 0
Biounits:
6s1n.pdb1.pdb ABCDEFG PT 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
zf-C4pol Domain P28340_1012-1082 8.1e-20 1 No_clan A 1012 1082   
DNA_pol_D_N Domain P49005_49-176 2.3e-31 1 CL0021 B 49 176   
PCNA_N Domain P12004_2-125 3.8e-60 1 CL0060 E 1 125   
PCNA_C Domain P12004_127-254 2.6e-58 1 CL0060 E 127 254   
PCNA_N Domain P12004_2-125 4.4e-58 1 CL0060 F 1 125   
PCNA_C Domain P12004_127-254 9.7e-58 1 CL0060 F 127 254 T  H-Bb 
PCNA_N Domain P12004_2-125 3.7e-60 1 CL0060 G 1 125   
PCNA_C Domain P12004_127-254 1.7e-56 1 CL0060 G 127 254   
DNA_pol_B Family P28340_541-973 8.5e-143 1 CL0194 A 541 973 PT  H-Bb S-Bb L-Bb 
DNA_pol_B_exo1 Family P28340_130-477 3.9e-84 1 CL0219 A 130 477 T  L-Mj 
DNA_pol_E_B Family P49005_196-412 3.8e-45 1 CL0163 B 196 412   
CDC27 Family Q15054_19-144 2e-60 1 CL0123 C 19 144   
DNA_pol_delta_4 Family Q9HCU8_42-97 5.4e-19 1 No_clan D 43 97   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=1-1107 C aggresome
A=1-1107 C cytosol
A=1-1107 C delta DNA polymerase complex
A=1-1107 C membrane
A=1-1107 C nucleoplasm
A=1-1107 C nucleotide-excision repair complex
A=1-1107 C nucleus
A=1-1107 F 3'-5'-exodeoxyribonuclease activity
A=1-1107 F 4 iron, 4 sulfur cluster binding
A=1-1107 F chromatin binding
A=1-1107 F damaged DNA binding
A=1-1107 F DNA binding
A=1-1107 F DNA-directed DNA polymerase activity
A=1-1107 F metal ion binding
A=1-1107 F nucleotide binding
A=1-1107 P base-excision repair, gap-filling
A=1-1107 P cellular response to UV
A=1-1107 P DNA biosynthetic process
A=1-1107 P DNA damage response, detection of DNA damage
A=1-1107 P DNA repair
A=1-1107 P DNA replication
A=1-1107 P DNA replication proofreading
A=1-1107 P DNA synthesis involved in DNA repair
A=1-1107 P DNA-dependent DNA replication
A=1-1107 P error-free translesion synthesis
A=1-1107 P fatty acid homeostasis
A=1-1107 P mismatch repair
A=1-1107 P nucleotide-excision repair, DNA gap filling
A=1-1107 P nucleotide-excision repair, DNA incision
A=1-1107 P nucleotide-excision repair, DNA incision, 5'-to lesion
A=1-1107 P response to UV
A=1-1107 P telomere maintenance
A=1-1107 P telomere maintenance via semi-conservative replication
A=1-1107 P transcription-coupled nucleotide-excision repair
A=1-1107 P translesion synthesis
B=1-469 C delta DNA polymerase complex
B=1-469 C DNA polymerase complex
B=1-469 C nucleoplasm
B=1-469 C nucleus
B=1-469 C zeta DNA polymerase complex
B=1-469 F DNA binding
B=1-469 P DNA biosynthetic process
B=1-469 P DNA damage response, detection of DNA damage
B=1-469 P DNA replication
B=1-469 P DNA strand elongation involved in DNA replication
B=1-469 P mismatch repair
B=1-469 P nucleotide-excision repair, DNA gap filling
B=1-469 P nucleotide-excision repair, DNA incision
B=1-469 P nucleotide-excision repair, DNA incision, 5'-to lesion
B=1-469 P telomere maintenance
B=1-469 P telomere maintenance via semi-conservative replication
B=1-469 P transcription-coupled nucleotide-excision repair
B=1-469 P translesion synthesis
C=2-466 C cytoplasm
C=2-466 C delta DNA polymerase complex
C=2-466 C nucleoplasm
C=2-466 C zeta DNA polymerase complex
C=2-466 F protein-macromolecule adaptor activity
C=2-466 P DNA biosynthetic process
C=2-466 P DNA damage response, detection of DNA damage
C=2-466 P DNA strand elongation involved in DNA replication
C=2-466 P DNA synthesis involved in DNA repair
C=2-466 P DNA synthesis involved in UV-damage excision repair
C=2-466 P mismatch repair
C=2-466 P nucleotide-excision repair, DNA gap filling
C=2-466 P nucleotide-excision repair, DNA incision
C=2-466 P nucleotide-excision repair, DNA incision, 5'-to lesion
C=2-466 P telomere maintenance
C=2-466 P telomere maintenance via semi-conservative replication
C=2-466 P transcription-coupled nucleotide-excision repair
C=2-466 P translesion synthesis
D=2-107 C delta DNA polymerase complex
D=2-107 C host cell nucleus
D=2-107 C nucleoplasm
D=2-107 P DNA damage response, detection of DNA damage
D=2-107 P DNA synthesis involved in DNA repair
D=2-107 P DNA-dependent DNA replication
D=2-107 P mismatch repair
D=2-107 P nucleotide-excision repair, DNA gap filling
D=2-107 P nucleotide-excision repair, DNA incision
D=2-107 P nucleotide-excision repair, DNA incision, 5'-to lesion
D=2-107 P telomere maintenance
D=2-107 P telomere maintenance via semi-conservative replication
D=2-107 P transcription-coupled nucleotide-excision repair
D=2-107 P translesion synthesis
E/F/G=1-261 C centrosome
E/F/G=1-261 C chromatin
E/F/G=1-261 C cyclin-dependent protein kinase holoenzyme complex
E/F/G=1-261 C extracellular exosome
E/F/G=1-261 C nuclear body
E/F/G=1-261 C nuclear chromosome, telomeric region
E/F/G=1-261 C nuclear lamina
E/F/G=1-261 C nuclear replication fork
E/F/G=1-261 C nucleoplasm
E/F/G=1-261 C nucleus
E/F/G=1-261 C PCNA complex
E/F/G=1-261 C PCNA-p21 complex
E/F/G=1-261 C replication fork
E/F/G=1-261 C replisome
E/F/G=1-261 F chromatin binding
E/F/G=1-261 F damaged DNA binding
E/F/G=1-261 F dinucleotide insertion or deletion binding
E/F/G=1-261 F DNA polymerase binding
E/F/G=1-261 F DNA polymerase processivity factor activity
E/F/G=1-261 F enzyme binding
E/F/G=1-261 F estrogen receptor binding
E/F/G=1-261 F histone acetyltransferase binding
E/F/G=1-261 F identical protein binding
E/F/G=1-261 F MutLalpha complex binding
E/F/G=1-261 F protein C-terminus binding
E/F/G=1-261 F protein-containing complex binding
E/F/G=1-261 F purine-specific mismatch base pair DNA N-glycosylase activity
E/F/G=1-261 F receptor tyrosine kinase binding
E/F/G=1-261 P base-excision repair, gap-filling
E/F/G=1-261 P cellular response to hydrogen peroxide
E/F/G=1-261 P cellular response to UV
E/F/G=1-261 P cellular response to xenobiotic stimulus
E/F/G=1-261 P DNA damage response, detection of DNA damage
E/F/G=1-261 P DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
E/F/G=1-261 P epithelial cell differentiation
E/F/G=1-261 P error-free translesion synthesis
E/F/G=1-261 P error-prone translesion synthesis
E/F/G=1-261 P estrous cycle
E/F/G=1-261 P heart development
E/F/G=1-261 P leading strand elongation
E/F/G=1-261 P liver regeneration
E/F/G=1-261 P mismatch repair
E/F/G=1-261 P mitotic telomere maintenance via semi-conservative replication
E/F/G=1-261 P negative regulation of transcription by RNA polymerase II
E/F/G=1-261 P nucleotide-excision repair, DNA gap filling
E/F/G=1-261 P nucleotide-excision repair, DNA incision
E/F/G=1-261 P nucleotide-excision repair, DNA incision, 5'-to lesion
E/F/G=1-261 P positive regulation of deoxyribonuclease activity
E/F/G=1-261 P positive regulation of DNA repair
E/F/G=1-261 P positive regulation of DNA replication
E/F/G=1-261 P positive regulation of DNA-directed DNA polymerase activity
E/F/G=1-261 P protein ubiquitination
E/F/G=1-261 P regulation of transcription involved in G1/S transition of mitotic cell cycle
E/F/G=1-261 P replication fork processing
E/F/G=1-261 P response to cadmium ion
E/F/G=1-261 P response to dexamethasone
E/F/G=1-261 P response to estradiol
E/F/G=1-261 P response to L-glutamate
E/F/G=1-261 P telomere maintenance
E/F/G=1-261 P telomere maintenance via semi-conservative replication
E/F/G=1-261 P transcription-coupled nucleotide-excision repair
E/F/G=1-261 P translesion synthesis
E/F/G=1-261 P viral process
Sequences
Download file with secondary structure created by Stride  
6s1n.pdb1.pdb:   [ download sequences in FASTA format ]
P (dna): 
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T (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (protein): 
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F (protein): 
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G (protein): 
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